Reversing Kratom Tolerance And Using Potentiators


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Related articles: What Does Kratom Feel Like?;   Mitragyna speciosa Strain Guide


                 Everyone loves kratom and for many of us, we all share one problem. The problem is tolerance builds over time. We don't want to stop for weeks or months just to reset our tolerance. The easiest thing you can do is avoid building a tolerance in the first place. This can be done by sticking to one specific dosage and keeping it at that, without increasing the dosage when you don't get an adequate buzz. You would be surprised what 6-8 hours of abstinence can do for you. I suggest a minimum of 6-8 hours abstinence as a daily practice. One or two doses daily is enough when used recreationally if you ask me. If you absolutely need it for pain or other ailments then that makes sense to take more than 2 doses daily.


How does tolerance work?


It's important to know how you build a tolerance to substances to begin with. When you take something repeatedly for a long period of time, or increase the dosage of a substance, your body finds way to basically lower the volume of the effects. Tolerance in general is basically from the production of metabolites that accumulate and interfere with the pharmacological response by either competing with the constituents or by a process known as down-regulation, which lowers the response of the receptor system that picks up on the chemicals you're using.[1] It's your bodies way of controlling something that your conscious mind refuses to control. It's funny how that works, no? I suggest listening to your body.


Strain Rotation


Kratom is a lot like Cannabis and Kava in the respect that its a plant with many different varieties, all of which produce their own unique effects. What causes these different varieties to have different psychoactive effects? Think about Cannabis for a second, and recall how Indica strains have more CBD than THC, and how Sativas have more THC than CBD. There are other alkaloids that vary from strain to strain, and they all effect the total outcome of the effects induced by each variety. Mitragyna speciosa contains far more alkaloids than just Mitragynine, and 5-hydroxymitragynine. It also contains Speciociliatine, Paynantheine, and Speciogynine.[2] A large number of factors effects the range and percentages of varoius constituents found in the plant, from environment, to when it's harvested, to even genetic factors.


Now that we understand that, I want to suggest a method for reversing your tolerance. Rotating between different Kratom strains is a common method used by enthusiast of the herb. This should help prevent a tolerance by giving your body different phytochemical constituents in varying degrees to work with. I've personally tried it and it works great. If you normally take Maeng Da, you could try switching to Borneo, or Bali, etc. It works wonders and I'm confident you'll be impressed.


Other Ways To Hack Your Biological Circuitry

Live Kratom Plants

Green Tea contains a phytochemical called Theanine or L-theanine. Many people swear by it as a potentiator. "It literally increases serotonin, dopamine, GABA, and glycine levels in multiple regions of the brain, as well as BDNF and NGF levels in certain brain areas."[3] This is likely the reason it's used in this way. These neurochemicals play a huge role in a lot of the euphoria and other sensations that people seek. It also contains alkaloids that are found to be inhibitors of Dopa decarboxylase.[4] It contains a lot of the same beneficial constituents as Mitragyna speciosa too.


Black Pepper ( contains Piperine )


Both pure piperine or Black pepper itself seems to enhance the psychoactive effects and medicinal properties. According to research, a study found that the use of piperinebuy piperine increased the bioavilability of curcumin by 2000%.[5] After learning about this, I decided to try it with other things to see if it could enhance their properties and stimulate the digestion. I was blown away when I tried this. It works remarkably and I suggest it to anyone. One thing that I've noticed though, is that when you try it the next day, it seems ineffective. This tells me the body responds to using it, and alters its chemistry or behavior in order to reverse the effects. It also seems like the second day if you don't use it that it works better. I have no idea why this is but it's consistently observable. Piperinebuy piperine and black pepper certainly come in handy. Oddly enough, I've also noticed that Kava seems to be a great potentiator of Kratom. It's also in the same family as the black pepper plant. Makes sense right? There are also a lot of herbs that have been used throughout history to improve digestion, like Ginger for example.


Agmatine

Agmatine is an amino acid. "It can potentiate opioid analgesia and prevent tolerance to chronic morphine in laboratory rodents. Cumulative evidence suggest that Agmatine inhibits opioid dependence and relapse in several animal species."[6] For this reason people swear by it as a potentiator. I personally use it and the results have been astounding. Given that you avoid taking excessive amounts of the herb, and practice the 6-8 hour abstinence between dosages, agmatine should work wonders for you.

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References:

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628209/

[2] https://jaoa.org/article.aspx?articleid=2094342

[3] Theanine. (2016, July 21). In Wikipedia, The Free Encyclopedia. Retrieved 15:38, July 28, 2016, from https://en.wikipedia.org/w/index.php?title=Theanine&oldid=530850802

[4] https://www.ncbi.nlm.nih.gov/pubmed/11354855

[5] https://www.ncbi.nlm.nih.gov/pubmed/9619120

[6] Su RB, Li J, Qin BY (July 2003). "A biphasic opioid function modulator: agmatine" (PDF). Acta Pharmacol. Sin. 24 (5): 6316. PMID 12852826.

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